Associate Professor Sandeep Prabhu (Sunny) is passionate about providing state of the art, contemporary, evidence-based treatments for the full spectrum of rhythm disorders. He is dedicated to ensuring patients receive the optimal treatment for their rhythm disorders.
He is also dedicated to advancing the field of electrophysiology through research, in particular clinical trials in atrial fibrillation and the role of catheter ablation. He has been nationally and internationally recognised for his research in the field of atrial fibrillation and heart failure. He has a particular interest in complex atrial fibrillation ablation.
Sunny focuses on:
• A patient-centred approach, tailoring treatments to your specific symptoms and goals.
• Engaging patients in their health care, particularly with the use of mobile technology.
• A focus on patient education and communication.
• Availing patients to ablation procedures (where appropriate) and utilising cutting edge technology for cardiac procedures.
• Integration of clinical practice and clinical research, availing patients to involvement in clinical trials and the latest approaches to treatments.
Sunny was one of a handful of undergraduate students to simultaneously graduate from both medicine and law (with honours in both) from Monash University (2005). He completed his internship and junior medical training at the Alfred Hospital.
He trained in Cardiology at the Alfred, Royal Melbourne and Frankston Hospitals and was admitted to the Royal Australasian College of Physicians in 2013.
He sub-specialised in electrophysiology and device implantation at the Alfred and Royal Melbourne Hospitals, in conjunction with a clinical PhD, before completing an overseas fellowship at St Bartholomew’s Hospital, London – Europe’s largest electrophysiology centre, focussing on catheter ablation.
2021 Appointed Clinical Associate Professor – University of Melbourne (Department of Medicine)
2021 Appointed Senior Research Fellow – Baker Heart and Diabetes Institute (Cardiometabolic Unit, Cardiac Electrophysiology)
2020 Appointed Honorary Research Fellow – University of Melbourne
2019 NHMRC Emerging Leader Research Fellow
2019 Heart Foundation Post-Doctoral Fellow
2019 Finalist Victorian Premiers Award for Health and Medical Research
2019 Nominee University of Melbourne Chancellors Award for Outstanding PhD.
2019 Completed European Heart Rhythm Association Accreditation Written Examination (Catheter Ablation)
2018 American College of Cardiology JACC EP Young Author Achievement Award
2018 Australian Government Endeavour Scholarship Award
2018 European Heart Rhythm Association International Training Fellowship Award
2018 Heart Lung and Circulation Review Article of the Year Award
2017 Baker Institute Highest Impact Publication Award
2017 Finalist CSANZ Ralph Reader Young Investigator Award
2016 Runner Up Asia Pacific Heart Rhythm Society Young Investigator Award.
2014 Finalist Asia Pacific Heart Rhythm Society Young Investigator Award.
2014 Heart Foundation Top Ranked Health Professional Scholar
2014 Heart Foundation Health Professional Scholarship
2014 NHMRC Postgraduate PhD Scholarship
2013 CSANZ Advanced Trainee Registrar Research Award
2011 & 2013 CSANZ Advanced Trainee Registrar Research Award
Sunny is an internationally recognised clinical researcher in the field of arrhythmia management with over 50 peer reviewed publications. He is a current holder of both the prestigious NHRMC Emerging Leader Research Grant, and a National Heart Foundation Post Doctorate Scholarship. He is currently involved in a co-ordination and running of a number of clinical trials and the co-supervision of several PhD students through the Alfred Hospital and the Baker Heart and Diabetes Institute.
Sunny was the co-ordinator and principle author of this landmark Australian randomised clinical trial evaluating the role of catheter ablation in patients with AF and otherwise unexplained heart failure. This study was published in the Journal of the American College of Cardiology in 2017, and has since been incorporated into national and international treatment guidelines.
Improvement in atrial scarring after catheter ablation or atrial fibrillation in heart failure. Long-Term Follow-Up of the CAMERA-MRI Study. This important study for the first time demonstrated that improvement in heart function following catheter ablation can improve scarring in the atria.
This paper was the first to describe that scarring of the heart that occurs in a weakened heart muscle due to atrial fibrillation, can be reversed after successful catheter ablation.
In concert with the Alfred and Baker, Sunny co-authored a landmark Australian clinical trial (led by colleague Dr Alex Voskoboinik) examining the role of alcohol in atrial fibrillation. This study was published in the world’s leading medical publication, the New England Journal of Medicine in 2020.
This study demonstrated that the improvements in heart function seen in patients with atrial fibrillation and otherwise unexplained heart failure, was maintained in the long term out to 4 years. (Recently accepted in JACC: Clinical Electrophysiology – July 2020)
This randomised clinical trial is a follow on study from CAMERA-MRI is evaluating the role of MRI detected heart scarring upon heart function after catheter ablation for atrial fibrillation in all patients with heart failure. This study is currently being conducted across several sites across Melbourne and the UK.
This randomised clinical trial plans to evaluate the need of ongoing heart failure medical therapy in patients with a fully recovered heart function following treatment of heart failure due to atrial fibrillation. This study will be performed across multiple sites in Melbourne and Internationally.
If you are interested in finding out more information about these studies or referring a patient for consideration, please contact Ms Sonia Azzopardi (Research Nurse Co-ordinator, Baker Heart and Diabetes Institute) +61 3 9076 3352
Chieng D, Sugumar H, Kaye D, Azzopardi S, Vizi D, Rossi E, Voskoboinik A, PRABHU S, Ling LH, Lee G, Kalman JM, Kistler PM. Prone & Supine 12 lead EKG Comparisons: implications for Cardiac assessment during prone ventilation for COVID-19. JACC Clin Electrophysiol (Accepted for publication April 2021)
Sugumar H, Chieng D, PRABHU S, Voskoboinik A, Anderson RD, Al-Kaisey A, Lee G, McLellan AJ, Morton JB, Taylor AJ, Ling LH, Kalman JM, Kistler PM. A prospective evaluation of the impact of individual RF applications for slow pathway ablation for AVNRT: markers of acute success. J Cardiovasc Electrophysiol. 2021 Apr 14. doi:10.1111/jce.15045.
PRABHU S, Kistler PM Can the Past Re-Shape the Future?: New Insights Into PVC-Mediated Cardiomyopathy From the CHF-STAT Trial and the Retelling of a Familiar Story JACC Clin Electrophysiol. 2021 Mar;7(3):391-394
Sugumar H, Nanayakkara S, Vizi D, Wright L, Chieng D, Leet A, Mariani JA, Voskoboinik A, PRABHU S, Taylor AJ, Kalman JM, Kistler PM, Kaye DM, Ling LH A prospective Study using invasive haemodynamic measurements following catheter ablation for AF and early HFpEF: STALL AF-HFpEF. Eur J Heart Fail. 2021 Feb 9. doi: 10.1002/ejhf.2122.
PRABHU S*, Ahluwalia N*, Tyebally SM, Dennis ASC, Malomo SO, Abiodun AT, Tyrlis A, Dhillon G, Segan L, Graham A, Honarbakhsh S, Sawhney V, Sporton S, Lowe M, Finlay M, Earley MJ, Lambiase P, Schilling RJ, Hunter RJ. Long-term outcomes of index cryoballoon ablation or point-by-point radiofrequency ablation in patients with atrial fibrillation and systolic heart failure J Cardiovasc Electrophysiol. 2021 Apr;32(4):941-948 (*Co-first authors)
Nalliah CJ, Wong GR, Lee G, Voskoboinik A, Kee K, Goldin J, Watts T, Linz D, Wirth D, Parameswaran R, Sugumar H, PRABHU S, McLellan A, Ling H, Joseph S, Morton JB, Kistler P, Sanders P, Kalman JM. Sleep apnoea has a dose-dependent effect on atrial remodelling in paroxysmal but not persistent atrial fibrillation: a high-density mapping study. Europace. 2021 Jan 14:euaa275. doi: 10.1093/europace/euaa275.
Ezeani M, PRABHU S*. Pathophysiology and therapeutic relevance of PI3K(p110α) protein in atrial fibrillation: A non-interventional molecular therapy strategy. Pharmacol Res. 2021 Mar;165:105415 (*Senior author)
Wong GR, Nalliah CJ, Lee G, Voskoboinik A, PRABHU S, Parameswaran R, Sugumar H, Anderson RD, Ling LH, McLellan A, Johnson R, Sanders P, Kistler PM, Fatkin D, Kalman JM. Genetic Susceptibility to Atrial Fibrillation Is Associated With Atrial Electrical Remodeling and Adverse Post-Ablation Outcome. JACC Clin Electrophysiol. 2020 Nov;6(12):1509-1521.
Chieng D, Lahiri A, Sugumar H, Al-Kaisey A, Parameswaran R, Anderson R, PRABHU S, Ling L, Morton J, Mclellean A, Lee G, Kalman JM, McGavigan AD, Kistler PM. Catheter ablation for focal atrial and ventricular tachycardia using the high density grid multi-polar mapping catheter (Accepted Journal of Cardiovascular Electrophysiology July 2020)
Sugumar H, PRABHU S, Costello B, Chieng D, Azzopardi S, Voskoboinik A, Parameswaran R, Wong G, Anderson R, Al-Kaisey A, Ling L, Kotschet E, Taylor A, Kalman J. Catheter Ablation Versus Medication in Atrial Fibrillation and Systolic Dysfunction: Late outcomes of CAMERA-MRI Study (Accepted JACC: Clinical Electrophysiology July 2020)
Sugumar H, Nanayakkara S, Chieng D, Wong GR, Parameswaran R, Anderson RD, Al-Kaisey A, Nalliah CJ, Azzopardi S, PRABHU S, Voskoboinik A, Lee G, McLellan AJ, Ling LH, Morton JB, Kalman JM, Kistler PM Arrhythmia recurrence is more common in females undergoing multiple catheter ablation procedures for persistent atrial fibrillation: Time to close the gender gap. Heart Rhythm. 2019 Dec 19. pii: S1547-5271(19)31121-X. doi: 10.1016/j.hrthm.2019.12.013.
Voskoboinik A, Kalman JM, De Silva A, Nicholls T, Costello BT, Nanayakkara S, PRABHU S, Stub D, Azzopardi S, Vizi D, Wong G, Nalliah C, Sugumar H, Wong M, Kotschet, Kaye D, Taylor AJ, Kistler PM. Alcohol Abstinence in Regular Drinkers with Atrial Fibrillation. New England Journal of Medicine (Accepted November 2019)
Honarbakhsh S, PRABHU S, Hunter J. With our powers combined….Does the pooled analysis of existing randomized data regarding treatment of atrial fibrillation in heart failure settle the case for catheter ablation? European Heart Journal doi:
10.1093/eurheartj/ehz704. [Epub ahead of print]
PRABHU S*, Sugumar H*, Voskoboinik A, Young S, Gutman SJ, Taylor AJ, Wong G, Parameswaran R, Nalliah CJ, Lee G, Mclellan AJA, Ling LH, Kalman JM, and Kistler PM. Atrial remodeling following catheter ablation for AF-mediated cardiomyopathy: long-term follow up of CAMERA MRI study (Accepted JACC EP March 2019) *Co-first Author
PRABHU S, Decoding Cardiac Electrophysiology Understanding the Techniques and Defining the Jargon. Chapter 1: The basic language of EP – An introduction to Intracardiac Electrograms. (Textbook Chapter) Radcliff Cardiology Publishing (Available January 2020)
Wong GR, Nalliah CJ, Lee G, Voskoboinik A, PRABHU S, Parameswaran R, Sugumar H, Anderson RD, McLellan A, Ling LH, Morton JB, Sanders P, Kistler PM and Kalman JM. Dynamic Atrial Substrate During High-Density Mapping of Paroxysmal and Persistent AF Journal of the American College of Cardiology: Clincial Electrophysiology. DOI: 10.1016/j.jacep.2019.06.002
PRABHU S, Lim WH, Schilling RJ. The Evolving Role of Catheter Ablation in Patients With Heart Failure and AF. Arrhythmia & Electrophysiology Review 2019;8(1):47–53.
Lim WH, PRABHU S, Schilling RJ. Implantable Cardiac Electronic Devices in the elderly population. Arrhythmia & Electrophysiology Review (2019, In press)
Voskoboinik A, Costello BT, La Gerche A, PRABHU S, Wong G, Flannery MD, Nalliah C, Sugumar H, Springer F, Kalman JM, Taylor AJ, Kistler PM. Relation of Alcohol Consumption to Left Ventricular Fibrosis Using Cardiac Magnetic Resonance Imaging. Am J Cardiol. 2019 Feb 1;123(3):460-465
Voskoboinik A, Moskovitch J, Plunkett G, Bloom J, Wong G, Nalliah C, PRABHU S, Sugumar H, Paramasweran R, McLellan A, Ling LH, Goh CY, Noaman S, Fernando H, Wong M, Taylor AJ, Kalman JM, Kistler PM. Cardioversion of atrial fibrillation in obese patients: Results from the Cardioversion-BMI randomized controlled trial. J Cardiovasc Electrophysiol. 2019 Feb;30(2):155-161
Voskoboinik A, Wong G, Lee G, Nalliah C, Hawson J, PRABHU S, Sugumar H, Ling LH, McLellan A, Morton J, Kalman JM, Kistler PM. Moderate alcohol consumption is associated with atrial electrical and structural changes: Insights from high-density left atrial electroanatomic mapping. Heart Rhythm. 2019 Feb;16(2):251-259
Sugumar H, PRABHU S, Voskoboinik A, Kistler PM. Arrhythmia induced cardiomyopathy. J Arrhythm. 2018 Jul 20;34(4):376-383
Voskoboinik A, PRABHU S, Sugumar H, Kistler PM. Effect of Dietary Factors on Cardiac Rhythm. Am J Cardiol. 2018 Oct 1;122(7):1265-1271
Voskoboinik A, Wong MCG, Elliott JK, Costello BT, PRABHU S, Mariani JA, Kalman JM, Kistler PM, Taylor AJ, Morton JB. Absence of late gadolinium enhancement on cardiac magnetic resonance imaging in ventricular fibrillation and non-ischemic cardiomyopathy. Pacing Clin Electrophysiol. 2018 Sep;41(9):1109-1115
PRABHU S, Kistler PM. Atrial Fibrillation, an Under-Appreciated Reversible Cause of Cardiomyopathy: Implications for Clinical Practice From the CAMERA-MRI Study. Heart Lung Circ. 2018 Jun;27(6):652-655.
Kistler PM, PRABHU S. Optimizing Catheter Contact and Improving Outcomes of Atrial Fibrillation Ablation: Jet Ventilation Avoids the Turbulence. JACC Clin Electrophysiol. 2018 Dec;4(12):1526-1528
PRABHU S, Taylor AJ, Costello BT, Kaye DM, Mclellan AJ, Voskoboinik A, Sugumar H, Lockwood SM, Stokes MB, Pathik B, Nalliah CJ, Wong GR, Azzopardi SM, Gutman S, Lee G, Layland J, Mariani JA, Ling L, Kalman JM and Kistler PM. Regression of Diffuse Ventricular Fibrosis following restoration of sinus rhythm with catheter ablation in Patients with Atrial Fibrillation and Systolic Dysfunction: a Sub-Study of the CAMERA MRI Trial. JACC: Clinical Electrophysiology 2018; 4(8): 999-1007.
PRABHU S, Kalla M, Peck KY, Mclellan AJA, Pathik B, Voskoboinik A, Nalliah CJ, Azzopardi S, Lee G, Ling L, Taylor AJ, Kalman JM, Kistler PM. Pulmonary vein activity does not predict outcome of catheter ablation for persistent atrial fibrillation – A long term multi-centre prospective study Heart Rhythm 2018;15(7):980-986
Sugumar H, Thomas SP, PRABHU S, Voskoboinik A, Kistler PM, How to perform posterior wall isolation in catheter ablation for atrial fibrillation Journal of Cardiovascular Electrophysiology 2018;29(2):345-352
PRABHU S, Taylor AJ, Costello BT, Kaye DM, Mclellan AJ, Voskoboinik A, Sugumar H, Lockwood SM, Stokes MB, Pathik B, Nalliah CJ, Wong GR, Azzopardi SM, Gutman S, Lee G, Layland J, Mariani JA, Ling L, Kalman JM and Kistler PM. Catheter Ablation versus Medical Rate control in Atrial fibrillation and systolic dysfunction (CAMERA-MRI)– An MRI guided multi-centre, randomised controlled trial. Journal of American College of Cardiology 2017; 70(16): 1949-1961
Cited: 139 times (as of Nov 2019)
Peak Altmetric Score: 229
Since incorporated into national and international (ACC/AHA) treatment guidelines for management of AF and heart failure – including practice update, up to date, CSANZ heart failure guidelines.
PRABHU S, Voskoboinik A, Mclellan JA, Peck KY, Pathik B, Nalliah CJ, Wong GR, Azzopardi SM, Lee G, Mariani JM, Ling L, Taylor AJ, Kalman JM, Kistler PM. Bi-atrial Electrical and Structural Atrial Changes in Heart Failure: Electro-anatomic Mapping in Persistent Atrial Fibrillation in Humans. JACC: Clinical Electrophysiology, 2018; 4(1): 87-96
Ranked most influential paper in 2019 for JACCEP (Invited presentation HRS AF Summit 2019, San Francisco)
Pathik B, Kalman JM, Walters T, Kuklik P, Zhao J, Madry A, PRABHU S, Nalliah C, Kistler P, Lee G. Transient Rotor Activity During Prolonged 3-Dimensional Phase Mapping in Human Persistent Atrial Fibrillation. JACC: Clinical Electrophysiology 2018; 4(1): 72-83
PRABHU S, McLellan AJA, Pathik B, Nalliah CJ, Voskoboinik A, Azzopardi SM, Lee G, Mariani J, Taylor AJ, Kalman JM, Kistler PM. A comparison of the electrophysiologic and electroanatomic characteristics between the right and left atrium in persistent atrial fibrillation: Is the right atrium a window into the left? Journal of Cardiovascular Electrophysiology 2017; 28(10): 1109-1116
PRABHU S, Kistler PM. The use of adenosine and ATP for the detection of dormant PV/LA conduction in atrial fibrillation ablation. Journal of Cardiovascular Electrophysiology 2017; 28(11): E6
Pathik B, Kalman J, Walters T, Kuklik P, Zhao J, Madry A, PRABHU S, Nalliah C, Kistler P, Lee G. Transient Rotor Activity During Prolonged Three-Dimensional Phase Mapping in Human Persistent Atrial Fibrillation JACC: Clinical Electrophysiology (Accepted June 2017)
PRABHU S, Voskobonik A, Kaye DM, Kistler PM Atrial Fibrillation and Heart Failure: Cause or Effect? (2017) Heart Lung and Circulation; 26: 967-974
McLellan AJ, PRABHU S, Voskoboinik A, Wong MC, Walters TE, Pathik B, Morris GM1, Nisbet A1, Lee G, Morton JB1, Kalman JM, Kistler PM. Isolation of the posterior left atrium for patients with persistent atrial fibrillation: routine adenosine challenge for dormant posterior left atrial conduction improves long-term outcome. Europace. 2017; 19(12): 1958-1966
Mclellan AJ, Kumar S, Smith C, Ling HL, PRABHU S, Kalman JM, Kistler PM. The role of adenosine challenge in catheter ablation for atrial fibrillation: A systematic review and meta-analysis.(2017) International Journal of Cardiology; 236: 253-261.
Voskobonik A, PRABHU S, Ling LH, Kalman JM and Kistler PM. Alcohol and atrial fibrillation: a sobering review Journal of the American College of Cardiology; 68(23): 2567-2576
PRABHU S, McLellan AJA, Mackin V, Phan T, McGlase D, Pathik B, Nalliah CJ, Voskoboinik A, Azzopardi SM, Lee G, MAriani J, Taylor AJ, Kalman JM, Kistler PM. Determining the Dose of Adenosine for Dormant Pulmonary Vein Conduction Following AF Ablation: Electrophysiological and Hemodynamic Assessment . Journal of Cardiovascular Electrophysiology; 28(1):13-22
Mclellan AJ, Ellims AH, PRABHU S, Voskoboinik A, Iles LM, Hare JL, Kaye DM, Macclocca I, MAriani JA, Kalman JM, Taylor AJ, Pistler PM. Diffuse Ventricular Fibrosis on Cardiac Magnetic Resonance Imaging Associates with Ventricular Tachycardia in Patients with Hypertrophic Cardiomyopathy. (2016) Journal of Cardiovascular Electrophysiology 27(5):571-80
PRABHU S*, Ling L-H*, Ullah W, Hunter RJ, Schilling RJ, McLellan AJ, Earley MJ, C. Sporton S, Voskoboinik A, Blusztein D, A. Mariani J, Lee G, J Taylor A, M Kalman J, M. Kistler P: The Impact of Known Heart Disease on Long-Term Outcomes of Catheter Ablation in Patients with Atrial Fibrillation and Left Ventricular Systolic Dysfunction: A Multicenter International Study. (2016) Journal of Cardiovascular Electrophysiology 27(3): 281-89 *Co-principle author
Ullah W, Ling LH, PRABHU S, Lee G, Kistler P, Finlay MC, Earley MJ, Sporton S, Bashir Y, Betts TR, Rajappan K, Thomas G, Duncan E, Staniforth A, Mann I, Chow A, Lambiase P, Schilling RJ, Hunter RJ. Catheter ablation of atrial fibrillation in patients with heart failure: impact of maintaining sinus rhythm on heart failure status and long term rates of stroke and death. (2016) Europace 18(5): 679-86
PRABHU S. Blusztein D, Jackson D, Sharma, M, Arunothayaraj, S, Stokes, M. B, Kras, A, Yi, H, Kong, L, Haji, K, Peck, K Casan, J. M, Toogood G. D, The Effect of Treatment Delays Associated with Inpatient Inter-hospital Transfer from Peripheral to Tertiary Hospitals for the Surgical Treatment of Cardiology Patients. (2016) Heart Lung Circulation. 25(1) 75-81
PRABHU S, Mclellan AJA, Walters TE, Sharma M, Voskoboinik A, Kistler PM. Atrial Structure and Function and its Implications for Current and Emerging Treatments for Atrial Fibrillation. (2015) Progress in Cardiovascular Diseases 58(2): 152-167
McLellan AJA, Schlaich MP, Taylor AJ, PRABHU S, Hering D, Hammond L, Marusic P, Duval J, Sata Y, Ellims A, Esler M, Peter K, Shaw J, Walton A, Kalman JM, Kistler PM. Reverse cardiac remodelling following renal denervation – atrial electrophysiologic and structural changes associated with blood pressure lowering. (2015) Heart rhythm 12: 982-990
Hagemeyer CE, Alt K, Johnston AP, Such GK, Ta HT, Leung MK, PRABHU S, Wang X, Caruso F, Peter K. Particle generation, functionalization and sortase A-mediated modification with targeting of single-chain antibodies for diagnostic and therapeutic use.(2015) Nature Protocols. Jan;10(1):90-105
PRABHU S, Mclellan A, Voskoboinik A, Kistler PM. Novel Uses of Imaging in AF ablation.(2012) Recent Patents in Cardiovascular Drug Discover; 8(2): 93-111
H.T. Ta, S PRABHU S. Leitner, F. Jia, D. von Elverfeldt, Katherine E. Jackson, T. Heidt, A.K.N. Nair, H. Pearce, C. von zur Muhlen, X. Wang, K. Peter, and C.E. Hagemeyer Enzymatic Single-Chain Antibody Tagging: A Universal Approach to Targeted Molecular Imaging and Cell Homing in Cardiovascular Disease (2011) Circulation Research; 109:365-373
PRABHU S, Sharma R, Ahrens I, Peter K – ‘Chapter Eleven: Platelets and the Pathogenesis of Vascular Disease and their Role as a Therapeutic Target’ – Mechanisms of Vascular Disease (2011) University of Adelaide Press. (Book Chapter)
Obeyesekere MN, Chan W, Stub D, PRABHU S, Teo EP, Toogood G, Mariani J, Broughton A, Kistler PM ‘Left ventricular ejection fraction and absence of ACE inhibitor/angiotensin II receptor blocker predicts appropriate defibrillator therapy in the primary prevention population’ (2010) Pacing Clin Electrophysiol 33(6):696-704.
DeWitt DE, Ward SA, PRABHU S, Warton B. ‘Patient privacy versus protecting the patient and the health system from harm: a case study’. (2009) Med J Aust. Aug 17;191(4):213-6